She was prime consort to Deathwing and mother of Nefarian and Onyxia. Her experiments led to the creation of a flight of twilight dragons which she planned to use to rule Azeroth. The wolves found her shadow-leading Cho'Gall's clan and breeding twilight whelps underneath the Bastion of Twilight.
Sinestra was really a strong enemy for the wolves, if it weren't the help of Calen (Caelestrasz), things would have been dire for them. In the end, the wolves were entitled as "Dragonslayers".
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